Objective:

To examine the polymorphisms of CD16, CD32, CD40, and CD152 in individuals with immune thrombocytopenia (ITP) through a systematic review, meta-analysis, and trial sequential analysis.

Approach:

Key Findings:

• Thirty-three studies were included in the analysis.
• A significant association was found for the FcγRIIIA-158 F/V polymorphism, with the highest odds ratio of 2.61 in the homozygous framework.
• No significant associations were detected for FcγRIIA-131 H/R, FcγRIIB-232 I/T, CTLA-4 exon 1 A49G, CTLA-4 CT60, CD40 rs4810485 G > T, and CD40 rs1883832 C > T polymorphisms.
• The greatest heterogeneity was observed in several frameworks for specific polymorphisms, notably FcγRIIA-131 H/R and CTLA-4 CT60.

Interpretation:

The FcγRIIIA-158 F/V variant is consistently linked to disease vulnerability across multiple genetic frameworks, while other variants did not show notable correlations.

Limitations:

• The study highlights the need for additional research to confirm the findings.
• Potential publication bias and heterogeneity in the included studies may affect the results.

Conclusion:

The findings suggest a specific genetic vulnerability associated with the FcγRIIIA-158 F/V variant in ITP, necessitating further studies.

Attribution Notice

This content is an AI-generated, fully rewritten summary based on a published scholarly article. It does not reproduce the original text and is not a substitute for the original publication. Readers are encouraged to consult the source for full context, data, and methodology.