Inflammaging and osteoarthritis - therapeutic opportunities - Summary - MDSpire

Inflammaging and osteoarthritis - therapeutic opportunities

  • By

  • Megan Chan

  • Phoebe Low

  • Shi Chee Ong

  • Sze Mun Choy

  • Wen Xing Lee

  • Kah Yong Goh

  • Kanya Moolsuwan Ng

  • Kimberly Chua

  • Jia Ying Lee

  • Alvin Kunyao Guo

  • Jiang Jia

  • Eng King Tan

  • Hong-Wen Tang

  • Kenon Chua

  • June 23, 2026

  • 0 min

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Objective:

To summarize the roles and mechanisms of the senescence-associated secretory phenotype (SASP) in osteoarthritis (OA) and explore therapeutic strategies targeting inflammatory factors.

Approach:
    Key Findings:
    • SASP is associated with chronic inflammation and cartilage degradation in OA.
    • Key pro-inflammatory cytokines in OA include IL-1β, TNF, and IL-6, which disrupt joint tissue homeostasis.
    • Therapeutic agents targeting SASP-related pathways show potential in reducing inflammation and preserving cartilage.
    Interpretation:

    The review highlights the role of SASP-driven inflammation in OA and the need for targeted therapeutic strategies.

    Limitations:
    • The review does not provide specific clinical trial data or outcomes related to the discussed therapeutic approaches, and emerging therapies such as microRNA modulation and CRISPR/Cas9 editing require further validation in clinical settings.
    Conclusion:

    Targeting SASP-related pathways may provide new avenues for managing OA.

Original Source(s)

Inflammaging and osteoarthritis - therapeutic opportunities

  • by Megan Chan, Phoebe Low, Shi Chee Ong, Sze Mun Choy, Wen Xing Lee, Kah Yong Goh, Kanya Moolsuwan Ng, Kimberly Chua, Jia Ying Lee, Alvin Kunyao Guo, Jiang Jia, Eng King Tan, Hong-Wen Tang, Kenon Chua

  • June 23, 2026

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