Deep brain stimulation of the hypothalamic region: a systematic review - Summary - MDSpire

Deep brain stimulation of the hypothalamic region: a systematic review

  • By

  • Mohammad Mofatteh

  • Abdulkadir Mohamed

  • Mohammad Sadegh Mashayekhi

  • Georgios P. Skandalakis

  • Clemens Neudorfer

  • Saman Arfaie

  • ArunSundar MohanaSundaram

  • Mohammadmahdi Sabahi

  • Ayush Anand

  • Rabii Aboulhosn

  • Xuxing Liao

  • Andreas Horn

  • Keyoumars Ashkan

  • February 4, 2025

  • 0 min

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Objective:

To review the functional organization of the hypothalamus and the effects of deep brain stimulation (DBS) on different hypothalamic regions for treating specific psychopathological and behavioral symptoms, including refractory headaches and aggressive behavior.

Key Findings:
  • 3,148 papers were identified, with 34 studies meeting inclusion criteria.
  • 412 patients were included, predominantly male (63.6%) and adults (73.5%).
  • Refractory chronic and chronic cluster headaches were the most common indications for DBS, affecting 57.8% of patients.
  • The posterior hypothalamus was the most frequently targeted area for DBS.
Interpretation:

DBS of the hypothalamus shows promise in treating various conditions, particularly refractory headaches and aggressive behavior, but further research, especially randomized controlled trials, is needed to establish efficacy and safety.

Limitations:
  • The review did not register in PROSPERO.
  • Limited to studies published in English.
  • Potential publication bias in included studies may affect the generalizability of findings.
Conclusion:

This systematic review highlights the potential of DBS in the hypothalamic region for treating specific psychological and neurological conditions, warranting further investigation, particularly in diverse populations and through rigorous study designs.

Original Source(s)

Deep brain stimulation of the hypothalamic region: a systematic review

  • by Mohammad Mofatteh, Abdulkadir Mohamed, Mohammad Sadegh Mashayekhi, Georgios P. Skandalakis, Clemens Neudorfer, Saman Arfaie, ArunSundar MohanaSundaram, Mohammadmahdi Sabahi, Ayush Anand, Rabii Aboulhosn, Xuxing Liao, Andreas Horn, Keyoumars Ashkan

  • February 4, 2025

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