To determine the relationship between longitudinal weight trajectory and the risk of ten prevalent cardiometabolic diseases among adults with similar high baseline BMI, including specific diseases such as type 2 diabetes and heart failure.
Key Findings:
Weight cycling is associated with a nearly 30% increased risk for obstructive sleep apnea (HR 1.28; 95% CI 1.15-1.42), metabolic dysfunction-associated steatotic liver disease (HR 1.28; 95% CI 1.08-1.51), and type 2 diabetes (HR 1.23; 95% CI 1.10-1.38).
Weight cycling correlates with over a 50% increased risk for heart failure (HR 1.54; 95% CI 1.31-1.82).
The risk associated with weight cycling is independent of high baseline BMI.
Interpretation:
The findings suggest that weight cycling may pose a greater risk for various cardiometabolic diseases compared to maintaining a high BMI or experiencing weight gain/loss, highlighting the need for targeted interventions.
Limitations:
The study is observational and may not establish causation.
Potential biases in self-reported weight data, such as inaccuracies in reporting and the exclusion of certain populations, may affect generalizability.
Conclusion:
Promoting weight stability or sustainable weight loss is crucial to mitigate the risk of cardiometabolic diseases in individuals with high BMI, as indicated by the study's findings.
Federal prosecutors allege that a Florida physician and research staff fabricated clinical trial records that were submitted into database systems used to evaluate investigational drugs.
