Objective:

To highlight the misdiagnosis of primary cutaneous diffuse large B-cell lymphoma (PC-DLBCL) in an 85-year-old male patient and the importance of multidisciplinary management in his treatment.

Approach:

• Case Presentation: An 85-year-old male with severe ulcerative skin lesions was misdiagnosed multiple times, initially diagnosed with skin allergy, skin cancer, and pemphigus before receiving appropriate treatment.
• Multidisciplinary Management: The patient underwent orthopedic debridement, autologous skin grafting, and R-miniCHOP immunochemotherapy.

Key Findings:

• PC-DLBCL is often misdiagnosed due to nonspecific cutaneous manifestations.
• Early pathological biopsy is crucial for accurate diagnosis and can prevent mismanagement.
• Multidisciplinary collaboration between orthopedics and hematology-oncology improved treatment outcomes.

Interpretation:

The case emphasizes the need for timely and accurate diagnosis of PC-DLBCL to prevent severe complications.

Limitations:

• The case study is based on a single patient, limiting generalizability.
• Potential biases in diagnosis and treatment may not be fully addressed, which could affect the findings.

Conclusion:

Multidisciplinary approaches are essential in managing PC-DLBCL.