Comparison of vacuum-assisted flexible ureteroscopy and percutaneous nephrolithotomy for 2–3 cm upper tract stones: a real-world cohort study - Summary - MDSpire

Comparison of vacuum-assisted flexible ureteroscopy and percutaneous nephrolithotomy for 2–3 cm upper tract stones: a real-world cohort study

  • By

  • Xixiang Chen

  • Xin Huang

  • Xu Chen

  • Guo Liu

  • Liang Wang

  • May 20, 2026

  • 0 min

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Objective:

To compare the perioperative and recovery outcomes of FV-UAS against standard PCNL for managing upper urinary tract stones measuring 2–3 cm, highlighting the significance of this comparison in clinical practice.

Key Findings:
  • FV-UAS group had a higher immediate SFR (92.75% vs. 76.59%, P = 0.0132), indicating statistical significance. SFR at 1 month was comparable between groups (98.55% vs. 91.49%, P = 0.1564).
Interpretation:

FV-UAS technique offers comparable stone clearance to PCNL with advantages in recovery time, postoperative pain, and safety profile, suggesting potential shifts in treatment protocols.

Limitations:
  • Study is retrospective and conducted at a single center, which may introduce biases and limit generalizability. The sensitivity of KUB/ultrasound for early residual fragment detection is limited.
Conclusion:

FV-UAS represents a compelling minimally invasive alternative for selected patients with 2–3 cm upper tract stones, providing excellent outcomes and a favorable safety profile, warranting further studies for validation.

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