Rates of hospitalization pre- and post-total pancreatectomy with islet autotransplantation for patients with pancreatitis - Summary - MDSpire
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Hospitalization Trends Before and After Total Pancreatectomy with Islet Autotransplantation in Patients with Pancreatitis

  • By

  • Niveditha Jagadesh

  • Anne Eaton

  • Megan B. Ghai

  • Guru Trikudanathan

  • Kathryn D. Robinson

  • Vikesh K. Singh

  • Jaimie D. Nathan

  • Srinath Chinnakotla

  • Maisam Abu-El-Haija

  • Syed A. Ahmad

  • Timothy B. Gardner

  • Luis F. Lara

  • Katherine Morgan

  • Sri Prakash Mokshagundam

  • Bashoo Naziruddin

  • Andrew Posselt

  • Martin Wijkstrom

  • Piotr Witkowski

  • Gregory Beilman

  • Melena D. Bellin

  • August 26, 2026

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Objective:

To evaluate hospitalizations, reoperations, emergency room visits, and clinic visits before and after total pancreatectomy with islet autotransplantation (TPIAT) in patients with chronic pancreatitis or recurrent acute pancreatitis.

Approach:
  • Study Design: A prospective observational study (POST) involving 384 patients across 12 U.S. medical centers who underwent TPIAT.
  • Data Collection: Health utilization metrics were collected through participant interviews, medical record reviews, and standardized questionnaires at baseline and follow-up intervals.
  • Statistical Analysis: Secondary analysis of POST data focusing on hospital admissions, complications, and healthcare encounters before and after TPIAT.
Key Findings:
  • Significant improvements in pain symptoms and quality of life were reported post-TPIAT.
  • Over 80% of patients maintained islet function at 1 year after surgery.
  • Fewer hospital admissions were noted in the first year post-TPIAT compared to preoperative periods.
Limitations:
  • Baseline health utilization data was unavailable for four patients.
  • Follow-up participation declined over the 4-year study period.
Conclusion:

The study provides insights into hospitalization trends and healthcare utilization following TPIAT, highlighting the need for further long-term evaluations.

Sources:

Original Source(s)

Rates of hospitalization pre- and post-total pancreatectomy with islet autotransplantation for patients with pancreatitis

  • by Niveditha Jagadesh, Anne Eaton, Megan B. Ghai, Guru Trikudanathan, Kathryn D. Robinson, Vikesh K. Singh, Jaimie D. Nathan, Srinath Chinnakotla, Maisam Abu-El-Haija, Syed A. Ahmad, Timothy B. Gardner, Luis F. Lara, Katherine Morgan, Sri Prakash Mokshagundam, Bashoo Naziruddin, Andrew Posselt, Martin Wijkstrom, Piotr Witkowski, Gregory Beilman, Melena D. Bellin

  • August 26, 2026

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