The Association Between Depression and Gastro-Oesophageal Reflux Disease (GERD): Findings from the UK Biobank Analysis - Summary - MDSpire

The Association Between Depression and Gastro-Oesophageal Reflux Disease (GERD): Findings from the UK Biobank Analysis

  • By

  • Julia Reizner

  • Dennis Freuer

  • Timo Schmitz

  • Jakob Linseisen

  • Christa Meisinger

  • January 8, 2026

  • 0 min

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Objective:

To investigate whether adults from the general population suffering from depression have an increased risk of developing GERD, with a focus on potential sex- and age-differences.

Key Findings:
  • Participants with depression had a significantly higher risk of developing GERD compared to those without depression (p < 0.05).
  • The association between depression and GERD was consistent across different age and sex groups.
Interpretation:

The findings suggest that depression may be a risk factor for the development of GERD, highlighting the need for integrated care approaches that address both mental and gastrointestinal health.

Limitations:
  • The study did not assess incident cases of depression occurring after baseline.
  • Data was reliant on self-reports and hospital records, which may introduce reporting bias and affect the reliability of the findings.
Conclusion:

This study provides evidence of a significant association between depression and the risk of developing GERD, warranting further research into the underlying mechanisms.

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