Discrimination of benign and malignant ovarian sex cord-stromal tumors through the analysis of clinical features, MR imaging, and MR-based radiomics - Summary - MDSpire

Discrimination of benign and malignant ovarian sex cord-stromal tumors through the analysis of clinical features, MR imaging, and MR-based radiomics

  • By

  • Shifang Tan

  • Lingjie Zhang

  • Zhexuan Yang

  • Xueyan Liu

  • Meiying Cheng

  • Mingsheng Yi

  • Honglei Shang

  • Zhanqi Feng

  • Jingxu Xu

  • Chencui Huang

  • Xiaoan Zhang

  • Xin Zhao

  • May 25, 2026

  • 0 min

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Objective:

To compare diagnostic performance of clinical parameters, conventional MRI, and radiomic signatures, and to develop a multimodal nomogram for differentiating benign from malignant ovarian sex cord-stromal tumors (SCSTs).

Key Findings:
  • Traditional model achieved highest AUCs: training 0.880 [95% CI: 0.807-0.946], validation 0.908 [95% CI: 0.797-0.989].
  • Radiomics model (T2&DWI) achieved AUCs: training 0.887 [95% CI: 0.802-0.955], validation 0.843 [95% CI: 0.684-0.963].
  • Combined model demonstrated optimal predictive performance: AUCs of 0.945 [95% CI: 0.892-0.985] in training and 0.914 [95% CI: 0.798-0.988] in validation cohorts.
Interpretation:

Limitations:
  • Retrospective design may introduce selection bias.
  • Limited generalizability due to single-center study.
  • Potential variability in MRI interpretation among radiologists.
Conclusion:

Original Source(s)

Discrimination of benign and malignant ovarian sex cord-stromal tumors through the analysis of clinical features, MR imaging, and MR-based radiomics

  • by Shifang Tan, Lingjie Zhang, Zhexuan Yang, Xueyan Liu, Meiying Cheng, Mingsheng Yi, Honglei Shang, Zhanqi Feng, Jingxu Xu, Chencui Huang, Xiaoan Zhang, Xin Zhao

  • May 25, 2026

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