Purpura as the initial manifestation of IgG4-related disease with concomitant systemic lupus erythematosus: a case report
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By
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Yi Wei
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Fuhua Chen
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Ruomeng Li
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Zhen Zhao
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Yajuan Huang
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June 22, 2026
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Objective:
To report a case of a 61-year-old man with purpura as the initial presentation of concurrent IgG4-related disease and systemic lupus erythematosus.
Approach:
Key Findings:
- Purpura was the initial manifestation of concurrent IgG4-related disease and systemic lupus erythematosus.
- The patient exhibited significant renal pathological overlap characterized by IgG4-related tubulointerstitial injury and lupus-induced mesangioproliferative glomerulonephritis.
- Treatment led to resolution of purpura and negative urine protein testing.
Interpretation:
Limitations:
- The study is based on a single case report, limiting generalizability.
- Long-term outcomes beyond the 8-month follow-up are not reported.
Conclusion: