Purpura as the initial manifestation of IgG4-related disease with concomitant systemic lupus erythematosus: a case report - Summary - MDSpire
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Initial Presentation of Purpura in a Patient with Concurrent IgG4-Related Disease and Systemic Lupus Erythematosus: A Case Study

  • By

  • Yi Wei

  • Fuhua Chen

  • Ruomeng Li

  • Zhen Zhao

  • Yajuan Huang

  • June 22, 2026

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Objective:

To report a case of a 61-year-old man with purpura as the initial presentation of concurrent IgG4-related disease and systemic lupus erythematosus.

Approach:
    Key Findings:
    • Purpura was the initial manifestation of concurrent IgG4-related disease and systemic lupus erythematosus.
    • The patient exhibited significant renal pathological overlap characterized by IgG4-related tubulointerstitial injury and lupus-induced mesangioproliferative glomerulonephritis.
    • Treatment led to resolution of purpura and negative urine protein testing.
    Interpretation:

    Limitations:
    • The study is based on a single case report, limiting generalizability.
    • Long-term outcomes beyond the 8-month follow-up are not reported.
    Conclusion:

Original Source(s)

Purpura as the initial manifestation of IgG4-related disease with concomitant systemic lupus erythematosus: a case report

  • by Yi Wei, Fuhua Chen, Ruomeng Li, Zhen Zhao, Yajuan Huang

  • June 22, 2026

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