Safety and efficacy of intravenous tPA after successful thrombectomy for large vessel occlusion: a retrospective study - Summary - MDSpire

Safety and efficacy of intravenous tPA after successful thrombectomy for large vessel occlusion: a retrospective study

  • By

  • Masashi Kotsugi

  • Tomoya Okamoto

  • Hiromichi Hayami

  • Kenta Nakase

  • Yudai Morisaki

  • Shohei Yokoyama

  • Ryosuke Matsuda

  • Shuichi Yamada

  • Ichiro Nakagawa

  • May 29, 2026

  • 0 min

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Objective:

To evaluate the efficacy and safety of adjunctive intravenous (IV) tissue plasminogen activator (tPA) administration following successful mechanical thrombectomy in patients with acute ischemic stroke caused by large vessel occlusion (LVO).

Key Findings:
  • text
Interpretation:

Adjunctive IV tPA administration following successful EVT may improve microvascular reperfusion and functional outcomes without increasing hemorrhagic complications, although careful patient selection is warranted.

Limitations:
  • Study is retrospective and not randomized.
  • Results are hypothesis-generating and require further validation in future prospective randomized trials.
Conclusion:

Adjunctive IV tPA may enhance outcomes post-thrombectomy, but further studies are needed to confirm these findings.

Original Source(s)

Safety and efficacy of intravenous tPA after successful thrombectomy for large vessel occlusion: a retrospective study

  • by Masashi Kotsugi, Tomoya Okamoto, Hiromichi Hayami, Kenta Nakase, Yudai Morisaki, Shohei Yokoyama, Ryosuke Matsuda, Shuichi Yamada, Ichiro Nakagawa

  • May 29, 2026

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