CTS Surgery Biopsies May Identify Early ATTR-CM - Summary - MDSpire
From the Journals

CTS Surgery Biopsies May Identify Early ATTR-CM

Biopsy-guided screening in older patients with idiopathic carpal tunnel syndrome detected mostly early-stage, often asymptomatic disease

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A multicenter cohort study indicates that biopsy-guided screening during carpal tunnel syndrome surgery can detect transthyretin amyloid cardiomyopathy (ATTR-CM) earlier in selected elderly patients. Among 109 patients undergoing surgery, 56% exhibited tenosynovial amyloid deposition, with 17% diagnosed with ATTR-CM. The findings reveal that screening identifies cases with less advanced disease and highlights underrecognition of the condition in women. However, the study's limitations include a lack of a screening log and a non-diverse cohort, suggesting further research is necessary.

Original Source(s)

CTS Surgery Biopsies May Identify Early ATTR-CM

  • by Andrea Surnit

  • April 21, 2026

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