To assess the frequency of cognitive impairment and depressive symptoms in MS and examine their independent impact on quality of life (QoL), emphasizing the significance of these factors beyond physical disability.
Key Findings:
Cognitive impairment was present in 47.9% and depressive symptoms in 61.3% of the cohort. EDSS showed the strongest correlation with QoL (MSIS-29 total score, r = 0.698, p < 0.001), followed by HAM-D (r = 0.438, p < 0.001) and BVMT-R (r = −0.340, p < 0.001).
Physical disability, depression, and processing speed were independent predictors of QoL, explaining 64% of its variance.
Interpretation:
While physical disability is the primary determinant of QoL in MS, cognitive impairment and depression also have significant independent effects, highlighting the need for routine screening and intervention in clinical practice.
Limitations:
Cross-sectional design limits causal inferences.
Potential selection bias due to specific inclusion criteria.
Assessment tools may not capture all aspects of cognitive and emotional functioning.
The geographical context may limit the generalizability of the findings.
Conclusion:
Addressing cognitive and mood disturbances is essential for improving overall well-being in MS patients, alongside managing physical disability, to enhance treatment outcomes.
Guidance addresses office readiness, recommended equipment and medications, and team communication processes for infrequent but high-acuity emergencies.
