To summarize B cell biology in lung transplantation, outline stage-specific perturbations, and explore the role of multi-omics technologies in supporting personalized immunomodulation and prognostic assessment.
Approach:
Multi-Omics Technologies: Explores how multi-omics platforms, including genomics, transcriptomics, and proteomics, can enhance immune monitoring and prognostic assessment across post-transplant phases.
Key Findings:
B cells play critical roles in both protective immunity and AMR in lung transplantation.
Dysregulation of B cells can result from ischemia-reperfusion injury, infection, and immunosuppressive therapies.
Emerging technologies like single-cell RNA sequencing enable detailed characterization of B cell dynamics.
Interpretation:
B cells are involved in the immune response following lung transplantation, influencing rejection and infection outcomes.
Limitations:
The review does not provide specific clinical recommendations or implications based on the findings.
Potential biases in the studies reviewed may affect the generalizability of the conclusions.
Conclusion:
Understanding B cell dynamics may contribute to improving outcomes in lung transplantation.
Heart rate monitoring and atrial fibrillation detection had the strongest supporting evidence, but investigators found limited evidence for broader outpatient self-monitoring applications.
