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American Epilepsy Society Clinical Practice Guideline: Infantile Epilepsy
This American Epilepsy Society (AES) practice guideline provides updated, evidence-based recommendations for the management of epilepsy in infants and children aged 1 month to <36 months.
To provide updated, evidence-based recommendations for the management of epilepsy in infants and children aged 1 month to <36 months.
Approach:
Guideline Development: Developed by a multidisciplinary expert panel, updating a prior systematic review and incorporating new evidence from August 2021 to September 2023.
Key Findings:
Two strong surgical recommendations for drug-resistant epilepsy include Hemispherectomy or hemispherotomy for specific unilateral lesional etiologies and focal, multilobar or posterior disconnection surgeries.
Interpretation:
The guideline emphasizes the need for higher-quality, etiology-specific data, particularly regarding long-term developmental outcomes and mortality in infants and young children with epilepsy.
Limitations:
Conditional recommendations due to limited high-quality data in this age group.
Conclusion:
A treatment algorithm is provided to help clinicians contextualize medical, dietary, and surgical options in practice.