American Epilepsy Society Clinical Practice Guideline: Infantile Epilepsy - Summary - MDSpire
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American Epilepsy Society Clinical Practice Guideline: Infantile Epilepsy

This American Epilepsy Society (AES) practice guideline provides updated, evidence-based recommendations for the management of epilepsy in infants and children aged 1 month to <36 months.

  • By

  • August 14, 2026

  • 2 min

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Objective:

To provide updated, evidence-based recommendations for the management of epilepsy in infants and children aged 1 month to <36 months.

Approach:
  • Guideline Development: Developed by a multidisciplinary expert panel, updating a prior systematic review and incorporating new evidence from August 2021 to September 2023.
Key Findings:
  • Two strong surgical recommendations for drug-resistant epilepsy include Hemispherectomy or hemispherotomy for specific unilateral lesional etiologies and focal, multilobar or posterior disconnection surgeries.
Interpretation:

The guideline emphasizes the need for higher-quality, etiology-specific data, particularly regarding long-term developmental outcomes and mortality in infants and young children with epilepsy.

Limitations:
  • Conditional recommendations due to limited high-quality data in this age group.
Conclusion:

A treatment algorithm is provided to help clinicians contextualize medical, dietary, and surgical options in practice.

Sources:

Original Source(s)

American Epilepsy Society Clinical Practice Guideline: Infantile Epilepsy

  • by

  • August 14, 2026

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