Post-styloid parapharyngeal neurogenic tumors: imaging-based prediction of nerve origin and clinical outcomes — a single-center retrospective case series - Summary - MDSpire

Post-styloid parapharyngeal neurogenic tumors: imaging-based prediction of nerve origin and clinical outcomes — a single-center retrospective case series

  • By

  • Pei-Han Liu

  • Hsiu-San Hsu

  • Chun-Hung Hua

  • Li-An Su

  • Wan-Ling Yi

  • Yung-An Tsou

  • Chia-Der Lin

  • Liang-Chun Shih

  • Chien-Chi Lu

  • June 23, 2026

  • 0 min

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Objective:

To evaluate the precision of imaging-derived nerve-of-origin predictions utilizing vessel displacement patterns, in relation to intraoperative validation.

Approach:
    Key Findings:
    • Fifteen individuals (average age 44.5 years; 67% male) were recognized.
    • A non-tender cervical mass was the most prevalent presenting symptom (53%).
    • Imaging indicated a vagal source in 11 tumors and a sympathetic chain source in 4 tumors.
    • Imaging accurately predicted the nerve of origin in 8 out of 9 patients (88.9%) who underwent surgical intervention, with one misidentified as vagal but confirmed as sympathetic intraoperatively.
    • Postoperative complications included vocal fold paralysis and Horner's syndrome in one patient each.
    Interpretation:

    Regular cross-sectional imaging of vessel displacement patterns could assist in the preoperative evaluation of nerve origin for post-styloid PPS neurogenic tumors.

    Limitations:
    • The study is based on a small sample size from a single institution, and further multicenter investigations with larger cohorts are required to validate these findings.
    Conclusion:

    Imaging-derived predictions of nerve origin may assist in surgical planning and risk assessment for patients with post-styloid PPS tumors.

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