IgG4-related autoimmune pancreatitis mimicking pancreatic carcinoma: a case report - Summary - MDSpire

IgG4-related autoimmune pancreatitis mimicking pancreatic carcinoma: a case report

  • By

  • Zejun Lu

  • Lijuan Wang

  • Ping Lu

  • Shangchao Cao

  • Bin Liu

  • Lei Li

  • Zhiqiang Jiang

  • Haiqiang Chu

  • Yingrong Xie

  • Jingbo Kang

  • June 18, 2026

  • 0 min

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Objective:

To report a case of autoimmune pancreatitis (AIP) that was initially misdiagnosed as pancreatic cancer due to similar imaging and serological findings.

Approach:
    Key Findings:
    • Serum IgG4 was markedly elevated at 10,022 μg/mL.
    • Histopathological examination revealed benign ductal epithelium with low proliferative activity and no evidence of adenocarcinoma.
    • Treatment with glucocorticoids resulted in normalization of serum IgG4 and CA19-9 levels.
    Interpretation:

    The case highlights the importance of including IgG4-related autoimmune pancreatitis in the differential diagnosis of pancreatic masses.

    Limitations:
    • The study is based on a single case report, which limits the generalizability of the findings.
    • Long-term outcomes beyond one year are not discussed.
    Conclusion:

    This case emphasizes the need for a systematic diagnostic approach in patients with pancreatic masses to differentiate between autoimmune pancreatitis and pancreatic cancer.

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