Objective:

To evaluate the validation of electrical impedance tomography (EIT) against computed tomography (CT) in nonintubated, spontaneously breathing subjects.

Approach:

Key Findings:

• EIT showed strong agreement with CT measurements when constrained to a 15 cm slab centered around the electrode plane, with minimal bias and acceptable limits of agreement in both posterior and right lung regions.
• No significant effect of biological sex, body mass index, fat percentage, or thoracic and abdominal circumference on EIT-CT agreement was observed.
• EIT captures meaningful features of regional lung function and reflects underlying changes in regional compliance and lung geometry.

Interpretation:

EIT-derived ventilation distribution may be robust across a range of anthropometric characteristics in healthy individuals.

Limitations:

• The study was conducted in healthy subjects, limiting generalizability to patients with lung pathology.
• Controlled breath-holds required for CT validation are difficult to achieve in patients with respiratory distress.

Conclusion:

EIT could be a valuable tool for assessing regional ventilation.

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