Autonomous Oxygen Titration for Maintaining Normoxemia in Acutely Ill Adults: The SAVE-O 2 AI Randomized - Summary - MDSpire
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Automated Oxygen Adjustment for Sustaining Normoxemia in Critically Ill Adults: Results from the SAVE-O 2 AI Trial

  • By

  • David J. Douin

  • John D. Rice

  • Mengli Xiao

  • Laurel E. Beaty

  • Claire J. Guo

  • Cori Withers

  • Amy Sullivan

  • Erin L. Anderson

  • Alex C. Cheng

  • Mary K. Banasiewicz

  • Matthew W. Semler

  • Bradley D. Lloyd

  • Amelia W. Maiga

  • Kevin W. Gibbs

  • Gregory R. Stettler

  • Akram Khan

  • Mitchell B. Sally

  • Franklin L. Wright

  • Arek J. Wiktor

  • Neil R. Aggarwal

  • Vikhyat S. Bebarta

  • Adit A. Ginde

  • SAVE-O AI Investigators

  • Laura G. Murphy

  • Erika V. Alor

  • Yvette R. Evans

  • Laura A. Aguilar-Marquez

  • Jessica Cwik

  • Katie Gray

  • Dagmawit Getachew

  • April Johnson

  • Jakea D. Johnson

  • Karen F. Miller

  • Tracy L. Morgan

  • Shannon K. Pugh

  • Edward T. Qian

  • Colleen Ratcliff

  • Sabrina A. Shipman

  • Adam Turner

  • Lakeysha C. Wiggins

  • Genesis Briceno

  • Aidan Flieger

  • Nola Iwasaki

  • Riya Mathew

  • Chloe K. Ouchida

  • Jose Pena

  • Edvinas Pocius

  • Emily Tribbet

  • Samantha Underwood

  • Heather L. Clark

  • Copeland Graham

  • Leigha Landreth

  • Lisa Parks

  • Darija Ward

  • October 1, 2026

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Objective:

To evaluate whether autonomous oxygen titration increases the proportion of time in normoxemia compared to usual care in hospitalized adults receiving supplemental oxygen.

Approach:
  • Trial Design: SAVE-O2 AI was a multicenter randomized clinical trial conducted at 4 tertiary care hospitals, enrolling hospitalized adults aged 18 years or older with acute respiratory illness, trauma, burns, or acute care surgery.
  • Intervention: Participants were randomized to receive either autonomous oxygen titration using the O2matic PRO100 device or usual care with manual oxygen titration by clinicians.
  • Monitoring: Participants wore two pulse oximeters for monitoring Spo2 levels, with the autonomous system adjusting oxygen flow based on readings.
Key Findings:
  • The trial aimed to maintain Spo2 levels between 90%-96% and reduce time spent in hypoxemia (Spo2 <88%).
  • Autonomous oxygen titration was hypothesized to improve time in normoxemia compared to manual adjustments.
Interpretation:

The trial assessed the effectiveness of autonomous oxygen titration in maintaining optimal oxygen saturation levels in critically ill patients.

Limitations:
  • The O2matic PRO100 device was not FDA cleared for clinical use in the US during the trial.
  • Exclusion criteria limited the generalizability of findings to certain patient populations.
Conclusion:

The SAVE-O2 AI trial aimed to provide insights into the effectiveness of autonomous oxygen titration in critically ill adults.

Sources:

Original Source(s)

Autonomous Oxygen Titration for Maintaining Normoxemia in Acutely Ill Adults: The SAVE-O 2 AI Randomized

  • by David J. Douin, John D. Rice, Mengli Xiao, Laurel E. Beaty, Claire J. Guo, Cori Withers, Amy Sullivan, Erin L. Anderson, Alex C. Cheng, Mary K. Banasiewicz, Matthew W. Semler, Bradley D. Lloyd, Amelia W. Maiga, Kevin W. Gibbs, Gregory R. Stettler, Akram Khan, Mitchell B. Sally, Franklin L. Wright, Arek J. Wiktor, Neil R. Aggarwal, Vikhyat S. Bebarta, Adit A. Ginde, SAVE-O AI Investigators, Laura G. Murphy, Erika V. Alor, Yvette R. Evans, Laura A. Aguilar-Marquez, Jessica Cwik, Katie Gray, Dagmawit Getachew, April Johnson, Jakea D. Johnson, Karen F. Miller, Tracy L. Morgan, Shannon K. Pugh, Edward T. Qian, Colleen Ratcliff, Sabrina A. Shipman, Adam Turner, Lakeysha C. Wiggins, Genesis Briceno, Aidan Flieger, Nola Iwasaki, Riya Mathew, Chloe K. Ouchida, Jose Pena, Edvinas Pocius, Emily Tribbet, Samantha Underwood, Heather L. Clark, Copeland Graham, Leigha Landreth, Lisa Parks, Darija Ward

  • October 1, 2026

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