To compare cerebral-limbic functional connectivity (FC) characteristics among patients with bipolar mania (BD-M), bipolar depression (BD-D), and healthy controls (HC) to enhance understanding for potential treatment strategies.
Key Findings:
No significant group differences in cerebral-limbic FC survived false discovery rate (FDR) correction, indicating that all reported abnormal FC patterns are exploratory and should be interpreted cautiously.
Interpretation:
Distinct cerebral-limbic FC patterns were observed in BD-M (reduced DMN FC) and BD-D (increased DMN FC), suggesting potential neurofunctional correlates of mood states and implications for future research.
Limitations:
All reported abnormal FC patterns were exploratory and lacked statistical validation at the individual connection level; findings require replication in larger independent cohorts, and the small sample size limits generalizability.
Conclusion:
The study provides preliminary insights into state-related differences in bipolar disorder, highlighting the need for further research to validate these findings in larger cohorts.
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