Whole-body computed tomography versus conventional skeletal survey in patients with multiple myeloma: a study of the International Myeloma Working Group - Summary - MDSpire

Whole-body computed tomography versus conventional skeletal survey in patients with multiple myeloma: a study of the International Myeloma Working Group

  • By

  • J Hillengass

  • L A Moulopoulos

  • S Delorme

  • V Koutoulidis

  • J Mosebach

  • T Hielscher

  • M Drake

  • S V Rajkumar

  • B Oestergaard

  • N Abildgaard

  • M Hinge

  • T Plesner

  • Y Suehara

  • K Matsue

  • N Withofs

  • J Caers

  • A Waage

  • H Goldschmidt

  • M A Dimopoulos

  • S Lentzsch

  • B Durie

  • E Terpos

  • August 25, 2017

  • 0 min

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Objective:

To compare the sensitivities of whole-body computed tomography (WBCT) and conventional skeletal survey (CSS) for detecting skeletal lesions in multiple myeloma and assess the prognostic relevance of additional lesions detected by WBCT, particularly in terms of clinical outcomes.

Key Findings:
  • WBCT detected lytic bone lesions in 54 patients (25.5%) not seen by CSS, while CSS identified lesions in 12 patients (5.7%) not detected by WBCT.
  • Overall, WBCT showed significantly higher sensitivity for detecting skeletal lesions compared to CSS (odds ratio 4.50; P<0.0001).
  • In 103 patients (48.6%), no lytic lesions were detected by either technique.
Interpretation:

WBCT is more sensitive than CSS for detecting skeletal lesions in multiple myeloma, potentially leading to earlier identification of bone disease, which may influence treatment decisions.

Limitations:
  • Some osseous locations, such as the cervical spine and sacral bone, were not included in CSS at certain centers, potentially affecting detection rates.
  • The study's retrospective nature may introduce selection bias.
Conclusion:

WBCT should be considered for improved detection of skeletal lesions in multiple myeloma, although the clinical relevance of earlier detection remains to be fully understood and warrants further investigation.

Original Source(s)

Whole-body computed tomography versus conventional skeletal survey in patients with multiple myeloma: a study of the International Myeloma Working Group

  • by J Hillengass, L A Moulopoulos, S Delorme, V Koutoulidis, J Mosebach, T Hielscher, M Drake, S V Rajkumar, B Oestergaard, N Abildgaard, M Hinge, T Plesner, Y Suehara, K Matsue, N Withofs, J Caers, A Waage, H Goldschmidt, M A Dimopoulos, S Lentzsch, B Durie, E Terpos

  • August 25, 2017

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