Evaluating Radiotherapy as a Consolidative Approach to Manage Oligoprogression in Metastatic Melanoma Patients Undergoing Systemic Treatment (CURB-Melanoma) - A Phase 2 Single-Arm Clinical Trial

By
Oded Icht
Alexander Sun
Philip Wong
Andrew McPartlin
Thiago Pimentel Muniz
Anna Spreafico
Samuel D. Saibil
J. Nicholas Lukens
Sana D Karam
John De Almeida
Marcus O. Butler
C. Jillian Tsai
July 6, 2026

Frontiers In Oncology

Objective:

To investigate whether stereotactic body radiation therapy (SBRT) or hypofractionated radiation to oligoprogressive sites can improve progression-free survival (PFS) in metastatic melanoma patients receiving first-line systemic therapy.

Approach:

Exploratory Analyses: Serial blood samples will be collected for analyses of circulating tumor DNA (ctDNA), mutant allele fraction, and immune profiling.

Key Findings:

Oligoprogression is defined as progression at limited sites while the majority of disease remains stable.
Prospective data supporting SBRT for oligoprogressive cancers are limited, especially in metastatic melanoma.
The trial aims to enroll 52 patients over 12 months with an additional 24 months of follow-up.

Interpretation:

Limitations:

The study is limited to a single-arm design, which may affect the generalizability of results.
No prior trials have specifically evaluated SBRT in oligoprogressive melanoma.

Conclusion:

The CURB-Melanoma trial is designed to assess the efficacy of SBRT in extending PFS in patients with oligoprogressive metastatic melanoma.

Sources:

ClinicalTrials.gov

Evaluating Radiotherapy as a Consolidative Approach to Manage Oligoprogression in Metastatic Melanoma Patients Undergoing Systemic Treatment (CURB-Melanoma) - A Phase 2 Single-Arm Clinical Trial

Objective:

Approach:

Key Findings:

Interpretation:

Limitations:

Conclusion:

Sources:

Original Source(s)

Consolidative use of radiotherapy to block oligoprogression in patients with metastatic melanoma on Systemic Therapy (CURB-Melanoma) - a single arm, phase 2 clinical trial

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