Consolidative use of radiotherapy to block oligoprogression in patients with metastatic melanoma on Systemic Therapy (CURB-Melanoma) - a single arm, phase 2 clinical trial - Summary - MDSpire

Consolidative use of radiotherapy to block oligoprogression in patients with metastatic melanoma on Systemic Therapy (CURB-Melanoma) - a single arm, phase 2 clinical trial

  • By

  • Oded Icht

  • Alexander Sun

  • Philip Wong

  • Andrew McPartlin

  • Thiago Pimentel Muniz

  • Anna Spreafico

  • Samuel D. Saibil

  • J. Nicholas Lukens

  • Sana D Karam

  • John De Almeida

  • Marcus O. Butler

  • C. Jillian Tsai

  • July 6, 2026

  • 0 min

Share

Objective:

To investigate whether stereotactic body radiation therapy (SBRT) or hypofractionated radiation to oligoprogressive sites can improve progression-free survival (PFS) in metastatic melanoma patients receiving first-line systemic therapy.

Approach:
  • Exploratory Analyses: Serial blood samples will be collected for analyses of circulating tumor DNA (ctDNA), mutant allele fraction, and immune profiling.
Key Findings:
  • Oligoprogression is defined as progression at limited sites while the majority of disease remains stable.
  • Prospective data supporting SBRT for oligoprogressive cancers are limited, especially in metastatic melanoma.
  • The trial aims to enroll 52 patients over 12 months with an additional 24 months of follow-up.
Interpretation:

Limitations:
  • The study is limited to a single-arm design, which may affect the generalizability of results.
  • No prior trials have specifically evaluated SBRT in oligoprogressive melanoma.
Conclusion:

The CURB-Melanoma trial is designed to assess the efficacy of SBRT in extending PFS in patients with oligoprogressive metastatic melanoma.

Sources:

Original Source(s)

Consolidative use of radiotherapy to block oligoprogression in patients with metastatic melanoma on Systemic Therapy (CURB-Melanoma) - a single arm, phase 2 clinical trial

  • by Oded Icht, Alexander Sun, Philip Wong, Andrew McPartlin, Thiago Pimentel Muniz, Anna Spreafico, Samuel D. Saibil, J. Nicholas Lukens, Sana D Karam, John De Almeida, Marcus O. Butler, C. Jillian Tsai

  • July 6, 2026

Related Content

Intraoperative technological advances and new frontiers in precision glioma surgery

Advances in the multimodal management of central nervous system solitary fibrous tumors

Head and neck squamous cell carcinoma with femoral metastasis: a case report and systematic review of current literature