The Prognostic Value of Red Cell Distribution Width-to-Albumin Ratio for 28-Day Mortality in Sepsis Patients: A Multicenter Analysis Based on the eICU Collaborative Research Database - Summary - MDSpire
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The Prognostic Value of Red Cell Distribution Width-to-Albumin Ratio for 28-Day Mortality in Sepsis Patients: A Multicenter Analysis Based on the eICU Collaborative Research Database
To explore the association between the red blood cell distribution width-to-albumin ratio (RAR) and 28-day all-cause mortality in adult patients with sepsis.
Key Findings:
28-day mortality rate was significantly higher in the high-RAR group (23.0%) compared to the low-RAR group (9.9%), P<0.001.
High RAR was independently associated with increased mortality (HR 1.50, 95% CI 1.36–1.64, P < 0.001).
Each unit increase in RAR was associated with an 8% higher risk of mortality (HR 1.08, 95% CI 1.07–1.10, P<0.001).
A non-linear dose-response relationship was observed, with mortality risk increasing with higher RAR levels.
Interpretation:
Limitations:
The clinical value of RAR in resource-limited settings needs further validation.
The study is retrospective and may be subject to biases inherent in such designs.
