Objective:

To summarize current knowledge of neural-mediated tumor progression across malignancies and its relevance to hepatocellular carcinoma (HCC).

Approach:

Key Findings:

• Neural activity promotes tumor proliferation, invasion, metastasis, therapeutic resistance, and immune evasion.
• Neural signals interact with canonical oncogenic pathways, enhancing tumor-promoting programs.
• Tumors actively remodel the nervous system, establishing feedback loops that facilitate progression.

Interpretation:

Limitations:

• Critical knowledge gaps exist regarding specific neural circuits involved in tumor progression.
• The temporal dynamics of innervation during disease progression are not fully understood.
• The intersection of neural pathways with canonical oncogenic drivers remains unclear.

Conclusion:

Attribution Notice

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