Pharmaceutical stability of compounded acetylcholine chloride intraocular solution for intracoronary provocative vasospasm testing - Summary - MDSpire

Pharmaceutical stability of compounded acetylcholine chloride intraocular solution for intracoronary provocative vasospasm testing

  • By

  • Killian J. McCarthy

  • Ryan Greenhalgh

  • Erica MacDonald

  • Laura Cedro

  • Duane Pinto

  • Margaret Stephan

  • Eric A. Osborn

  • June 3, 2026

  • 0 min

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Objective:

To characterize the stability of compounded acetylcholine (ACh) intraocular solutions according to current pharmacy guidelines for use in provocative intracoronary ACh vasospasm testing.

Key Findings:
  • The compounded ACh solution was clear and colorless with a pH of 4.2 across all time points.
  • Subvisible particulate matter remained within USP specifications.
  • 96.7 ± 0.3% of the initial ACh was retained at 12 hours, satisfying USP regulations.
Interpretation:

Remove this section.

Limitations:
  • The study only assessed stability for a 12-hour period.
  • The compounded solution was tested under specific storage conditions that may not reflect all clinical settings.
Conclusion:

Revise to strictly reflect findings without implications for clinical practice.

Original Source(s)

Pharmaceutical stability of compounded acetylcholine chloride intraocular solution for intracoronary provocative vasospasm testing

  • by Killian J. McCarthy, Ryan Greenhalgh, Erica MacDonald, Laura Cedro, Duane Pinto, Margaret Stephan, Eric A. Osborn

  • June 3, 2026

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