Objective:

To investigate the mucosal microbial signatures, dysbiosis characteristics, and potential biomarkers in PJS polyps versus paired normal small intestinal mucosa.

Approach:

Key Findings:

• Alpha diversity (Observed species, Chao1, Shannon) was markedly reduced in polyps (all P < 0.001), while Simpson index increased (P < 0.001).
• Beta diversity differed significantly between groups (ANOSIM, R = 0.0667, P = 0.002).
• Polyps were enriched in Pseudomonadota (70.00% vs. 49.51%, P < 0.001) and depleted in Bacillota, Bacteroidota (both P < 0.001).
• Microbial dysbiosis index (MDI) was higher in polyps (P < 0.001).
• A 9-genera random forest model achieved AUC = 0.897.
• Escherichia-Shigella correlated with polyp number (P < 0.05), and Enterococcus correlated with CA72–4 levels (P < 0.05).

Interpretation:

Limitations:

• The study was limited to a specific patient population and may not be generalizable.
• The reliance on a single method of microbiota profiling may overlook other microbial interactions.

Conclusion:

Source

Based on findings from:

Distinct mucosa-associated microbiota signatures and dysbiosis in Peutz-Jeghers syndrome polyps versus paired normal mucosa

Shuai Tang, Lei Wang, Chong-xi Fan, Zhe-yi Han, Lei Zhang, Bai-rong Li, Shou-Bin Ning. Frontiers In Immunology, 2026.

https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2026.1817311/full

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This content is an AI-generated, fully rewritten summary based on a published scholarly article. It does not reproduce the original text and is not a substitute for the original publication. Readers are encouraged to consult the source for full context, data, and methodology.