Objective:

To present a case of myeloid neoplasm with CCDC88C::PDGFRB rearrangement and atypical manifestations, including predominant neutrophilia.

Approach:

Key Findings:

• The case highlights a myeloid neoplasm with CCDC88C::PDGFRB rearrangement presenting with neutrophilia instead of eosinophilia, and without an increase in blasts.
• Rapid response to low-dose imatinib was observed, maintaining hematologic remission.

Interpretation:

This case expands the clinicopathologic spectrum of CCDC88C::PDGFRB-rearranged neoplasms and highlights the role of RNA sequencing in identifying actionable kinase fusions.

Conclusion:

The findings contribute to understanding atypical presentations of myeloid neoplasms.

Attribution Notice

This content is an AI-generated, fully rewritten summary based on a published scholarly article. It does not reproduce the original text and is not a substitute for the original publication. Readers are encouraged to consult the source for full context, data, and methodology.