Objective:

To evaluate the safety of omitting antibiotic prophylaxis in transperineal prostate biopsy without periinterventional screening for bacteriuria, highlighting its relevance to current clinical practices.

Key Findings:

• Omission of antibiotic prophylaxis did not significantly increase postinterventional infectious complications, with a specific rate of complications reported.
• General complication rates were assessed and categorized by various risk factors, providing detailed statistics.
• The study highlights the potential for reducing antibiotic use in prostate biopsies, suggesting a specific percentage reduction.

Interpretation:

The findings suggest that transperineal prostate biopsy can be safely performed without antibiotic prophylaxis, which may have significant implications for antibiotic stewardship and clinical guidelines.

Limitations:

• Selection bias due to the retrospective nature of the study, which may limit generalizability.
• Follow-up bias from reliance on chart reviews for postinterventional complications, potentially underreporting issues.

Conclusion:

Omitting antibiotic prophylaxis in transperineal prostate biopsies appears safe, potentially reducing unnecessary antibiotic use and addressing public health concerns regarding antibiotic resistance, which is critical in the current healthcare landscape.