Intravenous thrombolysis for acute ischemic stroke in the extended time window of 4.5–24 h: a systematic review and network meta-analysis of randomized controlled trials - Summary - MDSpire
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Intravenous thrombolysis for acute ischemic stroke in the extended time window of 4.5–24 h: a systematic review and network meta-analysis of randomized controlled trials
To systematically evaluate the efficacy and safety of different intravenous thrombolytic agents in patients with acute ischemic stroke (IS) who present between 4.5 and 24 h after symptom onset.
Key Findings:
Clarify certainty levels for all results.
Interpretation:
Remove unsupported conclusions.
Limitations:
The certainty of the evidence was predominantly low to very low, limited by risk of bias, imprecision, and indirectness.
JX10's findings are derived from a single, small-sample, dose-exploratory study with no direct comparative data.
Conclusion:
Revise to reflect only the findings presented without unsupported claims.
