Objective:

To systematically summarize the role of non-coding RNAs (ncRNAs) in cardiovascular complications associated with SARS-CoV-2 infection.

Approach:

• Pathophysiological Mechanisms: Delineates established mechanisms of SARS-CoV-2-induced cardiovascular damage and dysregulated ncRNA expression profiles.
• Mechanistic Insights: Explores how ncRNAs orchestrate key pathological events such as cardiac inflammation, programmed cell death, and thrombogenesis.
• Intercellular Communication: Discusses the role of ncRNAs in mediating intercellular and systemic communication, particularly within the cardio-immune axis.
• Translational Potential: Evaluates ncRNAs as potential diagnostic and prognostic biomarkers and therapeutic targets.

Key Findings:

• SARS-CoV-2 infection leads to significant cardiovascular complications, including myocardial injury and increased mortality.
• Non-coding RNAs (miRNAs, lncRNAs, circRNAs) are involved in regulating cardiac injury mechanisms related to SARS-CoV-2.
• Dysregulated ncRNA expression is associated with inflammation, cell death, and thrombosis in COVID-19 patients.

Interpretation:

This review summarizes the interplay between SARS-CoV-2 and cardiovascular health, focusing on the roles of ncRNAs.

Limitations:

• Challenges remain in fully elucidating the specific regulatory networks of ncRNAs.
• The clinical applications of ncRNAs as biomarkers and therapeutic targets are still under investigation.

Conclusion:

Understanding ncRNA biology in the context of cardiovascular disease from SARS-CoV-2 infection presents avenues for future research.