INVA8001, a novel and highly selective chymase inhibitor, ameliorates liver inflammation, fibrosis, and hyperplasia in Mdr2 knockout mice - Summary - MDSpire

INVA8001, a novel and highly selective chymase inhibitor, ameliorates liver inflammation, fibrosis, and hyperplasia in Mdr2 knockout mice

  • By

  • Sameer Sharma

  • Lixian Chen

  • Tianhao Zhou

  • Meenakshi Chawla

  • Anita Ganjoo

  • Shunichiro Okada

  • Salvatore Alesci

  • Krishnan Nandabalan

  • Heather Francis

  • June 9, 2026

  • 0 min

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Objective:

To examine the efficacy of INVA8001, a selective chymase inhibitor, in reducing liver inflammation, fibrosis, and hyperplasia in Mdr2 knockout mouse models of primary sclerosing cholangitis (PSC).

Key Findings:
  • Increased numbers of chymase-positive cells were observed in liver biopsies from PSC patients compared to controls.
  • INVA8001 treatment led to reduced chymase activity and decreased mast cell accumulation, inflammation, and fibrosis in Mdr2−/− mice.
  • Histological damage, ductular reaction, and biliary senescence were also significantly reduced following treatment.
Interpretation:

Limitations:
  • The study was conducted in a mouse model, which may not fully replicate human disease.
  • Further research is needed to explore the long-term effects and safety of INVA8001 in humans.
Conclusion:

Original Source(s)

INVA8001, a novel and highly selective chymase inhibitor, ameliorates liver inflammation, fibrosis, and hyperplasia in Mdr2 knockout mice

  • by Sameer Sharma, Lixian Chen, Tianhao Zhou, Meenakshi Chawla, Anita Ganjoo, Shunichiro Okada, Salvatore Alesci, Krishnan Nandabalan, Heather Francis

  • June 9, 2026

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