Objective:

To evaluate if plasma renin levels assessed at 72 hours (T0), 120 hours (T1), and 168 hours (T2) following ICU admission correlate with 1-year mortality in ARDS patients.

Approach:

Key Findings:

• 46% of patients (48 out of 104) died within one year.
• Elevated renin levels were linked to 1-year mortality at T0 (OR 1.94; 95% CI not provided; p = 0.002), T1 (OR 1.69; 95% CI not provided; p = 0.014), and T2 (OR 2.52; 95% CI not provided; p < 0.001).
• Kaplan–Meier survival curves showed significant divergence at T0 and T2 (log-rank p < 0.001).
• Independent predictors of mortality included renin at T0 (adjusted OR 5.15; 95% CI 1.34–19.78; p = 0.017), PaO₂/FiO₂ ratio at T0 (OR 0.02; 95% CI not provided; p = 0.010), and procalcitonin at T2 (OR 81.89; 95% CI not provided; p = 0.020).
• The model demonstrated high discrimination performance (AUC 0.941).

Interpretation:

Limitations:

• Single-center study may limit generalizability.
• Retrospective design may introduce biases.

Conclusion:

Serial patterns of renin levels offer further prognostic insights.

Source

Based on findings from:

Renin and 1-year mortality in critically ill patients with ARDS: trajectories, discrimination, and survival analysis

Gabriele Melegari, Alessandro Belletti, Federica Arturi, Antonio Giansante, Arianna Gaspari, Fabio Gazzotti, Elisabetta Bertellini, Giovanni Landoni, Alberto Barbieri. Frontiers In Medicine, 2026.

https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2026.1806797/full

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