Systematic review: digital biomarkers of fatigue in chronic diseases - Summary - MDSpire

Systematic review: digital biomarkers of fatigue in chronic diseases

  • By

  • Nana Yaw Aboagye

  • Chloe Hinchliffe

  • Silvia Del Din

  • Wan-Fai Ng

  • Kenneth F. Baker

  • Mark R. Baker

  • October 8, 2025

  • 0 min

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Objective:

To explore the relationship between digital biomarkers from wearable devices and fatigue in patients with various chronic diseases.

Key Findings:
  • Reduced physical activity, increased sedentary behavior, and autonomic dysfunction are associated with fatigue levels across multiple chronic diseases.
  • The strength of the association and specific biomarkers vary across different diseases, highlighting the need for disease-specific approaches.
  • Digital biomarkers can complement self-reported fatigue measures, providing a more comprehensive understanding of fatigue.
Interpretation:

Digital biomarkers provide an objective means to measure fatigue, which is often subjective and varies widely among individuals with chronic illnesses, emphasizing the importance of integrating these measures with self-reported data.

Limitations:
  • Variability in study quality and design among the included articles.
  • Limited generalizability due to the focus on specific chronic diseases.
  • Potential biases in self-reported fatigue measures may affect the findings.
Conclusion:

Digital biomarkers represent a promising approach to monitor and manage fatigue in chronic diseases, potentially leading to personalized care strategies.

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