To evaluate the association between coagulation indicators and multiple adverse outcomes in patients with Acute Fatty Liver of Pregnancy (AFLP) and identify key indicators that can predict disease severity.
Key Findings:
INR and PT showed the strongest predictive performance for composite adverse outcomes (AUC 0.837 for both).
VIF analysis indicated severe multicollinearity for PT, while INR was independently associated with higher rates of MODS, DIC, and postpartum hemorrhage.
61.95% of patients were admitted to ICU, with higher rates in those undergoing cesarean delivery and those under 37 weeks of gestation.
Interpretation:
Coagulation function indicators are strongly associated with adverse clinical events in AFLP, with INR providing improved risk stratification performance, highlighting its potential role in clinical decision-making.
Limitations:
The study is retrospective and may be subject to selection bias.
The preliminary indicator requires external validation before routine clinical use, and the sample size may limit generalizability.
Conclusion:
Coagulation indicators, particularly INR, may support clinical decision-making in AFLP, but further validation is necessary to confirm their utility.
Phase 3 ENHANCE-1 results showed higher composite clinical cure and microbiologic response rates with cefepime-zidebactam vs meropenem in hospitalized adults with complicated urinary tract infection or acute pyelonephritis.
