To describe clinical and immunological features of Lyme neuroborreliosis (LNB) in children and characterize distinct LNB subgroups, focusing on their clinical manifestations and immune responses.
Key Findings:
Meningitis was the most frequent manifestation (60.5%), followed by isolated cranial neuropathy (28.9%) and meningoradiculitis (7.9%).
Facial palsy was the most common specific clinical sign (71.6%).
Distinct subgroups were identified: iCN reflects localized PNS involvement, while meningitis and meningoradiculitis indicate systemic involvement.
Interpretation:
The findings suggest a broad clinical spectrum of LNB in children, with distinct pathogenic subgroups that may aid in diagnosis and management.
Limitations:
The study is retrospective and conducted at a single center, which may limit generalizability and the applicability of findings to broader populations.
Diagnostic guidelines for LNB in children are not fully validated.
Conclusion:
Characterization of LNB subgroups can enhance diagnostic accuracy and inform treatment strategies for pediatric patients.
by Semjon Sidorov, Beat M Greiter, Ester Osuna, Annette Hackenberg, Michelle Seiler, Roland Martin, Martina Marchesi, Stefanie von Felten, Adrian Egli, Christoph Berger, Patrick M Meyer Sauteur
