Specific IgG levels before and one month after administration of a booster dose of the diphtheria, tetanus, and pertussis vaccine in 14-year-old adolescents - Summary - MDSpire

Specific IgG levels before and one month after administration of a booster dose of the diphtheria, tetanus, and pertussis vaccine in 14-year-old adolescents

  • By

  • Kostinov, Mikhail

  • Prutskova, Ekaterina

  • Mekhantseva, Irina

  • Cherdantsev, Alexander

  • Solovеva, Irina

  • Polishchuk, Valentina

  • Zhestkov, Alexander

  • Khamidulina, Anna

  • Dementeva, Yuliya

  • Kostinov, Anton

  • Khrapunova, Isabella

  • Loktionova, Marina

  • Tarasova, Alla

  • Kvasova, Maria

  • Poddubikov, Arseniy

  • Pal, Nidhi Harish

  • Kostinova, Aristitsa

  • June 2, 2026

  • 0 min

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Objective:

To evaluate the immunological impact of booster vaccination against diphtheria, tetanus, and Bordetella pertussis in 14-year-old adolescents.

Approach:
    Key Findings:
    • All participants had protective immunity to tetanus at baseline.
    • 1.7% lacked protective antibody levels against diphtheria and 6.9% against pertussis.
    • Booster vaccination significantly increased anti-diphtheria IgG levels across all groups.
    • High levels of tetanus-specific antibodies were achieved, particularly in the Td-M group.
    • Pertussis-specific IgG responses were heterogeneous with no overall increase post-vaccination.
    • Tdap-M maintained more stable antibody levels compared to Tdap.
    • All vaccines were well-tolerated with only mild adverse events reported.
    Interpretation:

    The findings indicate that while adolescent booster vaccination effectively reinforces immunity against diphtheria and tetanus, the lack of significant increase in pertussis-specific IgG suggests limited booster-induced response due to pre-existing immunity.

    Limitations:
    • The study does not address long-term immunity beyond one month post-vaccination.
    • The sample size for each vaccine group may limit the generalizability of the findings.
    Conclusion:

    The study raises questions about the necessity of routine pertussis revaccination at 14 years.

Original Source(s)

Specific IgG levels before and one month after administration of a booster dose of the diphtheria, tetanus, and pertussis vaccine in 14-year-old adolescents

  • by Kostinov, Mikhail , Prutskova, Ekaterina , Mekhantseva, Irina , Cherdantsev, Alexander , Solovеva, Irina , Polishchuk, Valentina , Zhestkov, Alexander , Khamidulina, Anna , Dementeva, Yuliya , Kostinov, Anton , Khrapunova, Isabella , Loktionova, Marina , Tarasova, Alla , Kvasova, Maria , Poddubikov, Arseniy , Pal, Nidhi Harish, Kostinova, Aristitsa

  • June 2, 2026

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