Circulating biomarkers improve prediction of postoperative outcome after aortic valve surgery - Summary - MDSpire

Circulating biomarkers improve prediction of postoperative outcome after aortic valve surgery

  • By

  • Till Joscha Demal

  • Jenny Bialczak

  • Alina Goßling

  • Francisco Miguel Ojeda

  • Oliver Daniel Bhadra

  • Björn Sill

  • Johannes Petersen

  • Sebastian Ludwig

  • David Grundmann

  • Lisa Voigtländer

  • Lara Waldschmidt

  • Laura Hannen

  • Niklas Schofer

  • Stefan Blankenberg

  • Paulus Kirchhof

  • Thomas Renné

  • Lenard Conradi

  • Hermann Reichenspurner

  • Evaldas Girdauskas

  • Andreas Schaefer

  • June 2, 2026

  • 0 min

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Objective:

To investigate the association between preoperative circulating biomarkers and postoperative mortality and morbidity in patients undergoing aortic valve surgery.

Key Findings:
  • Preoperative hemoglobin, creatinine, hsTrop-I, GOT, INR, CRP, NT-proBNP, and WBC were independently associated with 30-day mortality.
  • Models combining biomarkers with EuroSCORE-II outperformed those predicting mortality by EuroSCORE-II or biomarkers alone.
Interpretation:

Limitations:
  • The study was conducted at a single center, which may limit generalizability.
  • Patients undergoing concomitant procedures were included, which could affect outcomes.
Conclusion:

Original Source(s)

Circulating biomarkers improve prediction of postoperative outcome after aortic valve surgery

  • by Till Joscha Demal, Jenny Bialczak, Alina Goßling, Francisco Miguel Ojeda, Oliver Daniel Bhadra, Björn Sill, Johannes Petersen, Sebastian Ludwig, David Grundmann, Lisa Voigtländer, Lara Waldschmidt, Laura Hannen, Niklas Schofer, Stefan Blankenberg, Paulus Kirchhof, Thomas Renné, Lenard Conradi, Hermann Reichenspurner, Evaldas Girdauskas, Andreas Schaefer

  • June 2, 2026

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