Objective:

To investigate surgical high-risk zones within a (C)RT cohort to identify predictors of radiation failure in T2-T3 glottic carcinoma patients.

Approach:

Key Findings:

• Vertical anterior commissure involvement was identified as a predictive factor for radiation failure.
• Horizontal anterior commissure involvement and deep vocal muscle infiltration showed non-significant trends toward poorer outcomes.
• The study highlights the need for stratification of tumors treated with (C)RT based on surgical risk factors.

Interpretation:

Understanding tumor behavior and recurrence patterns is essential for comparing treatment options.

Limitations:

• The study is retrospective and may have inherent biases that could affect the results.
• Most relevant studies on this topic date back several years, which may limit the applicability of findings.

Conclusion:

The study aims to clarify the oncological outcomes of (C)RT for specific tumor growth patterns in T2-T3 glottic carcinoma.

Source

Based on findings from:

Radiological risk factors for T2-T3 glottic carcinoma treated with (chemo)radiotherapy—a multicenter analysis

Agatha S. Baidun, Yves M. H. F. Gorissen, Martine Hendriksma, Renske Gahrmann, Jose A. Hardillo, Sjoert Pegge, Robert P. Takes, Guido B. van den Broek, Martin A. de Jong, Federica Lucev, Elisabeth V. Sjogren, Berit M. Verbist. European Radiology, 2026.

https://link.springer.com/article/10.1007/s00330-026-12704-3

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