To compare the efficacy and safety of BEAM/ATG and Cy/ATG conditioning regimens in autologous haematopoietic stem cell transplantation for patients with relapsing-remitting multiple sclerosis (RRMS) specifically diagnosed before January 1, 2020.
Key Findings:
Both BEAM/ATG and Cy/ATG regimens resulted in high rates of clinical remission in RRMS patients.
The safety profile improved with the use of intermediate-intensity conditioning regimens compared to earlier high-intensity regimens.
Current data do not clarify the comparative efficacy of BEAM/ATG versus Cy/ATG.
Interpretation:
The findings suggest that both conditioning regimens are effective in inducing remission in RRMS, but further studies are essential to determine which regimen is superior in terms of long-term outcomes.
Limitations:
The study is observational and retrospective, which may introduce bias.
Data accuracy relies on the thoroughness of electronic patient records and registry data, and potential confounding factors were not fully addressed.
Conclusion:
Both BEAM/ATG and Cy/ATG are viable options for ASCT in RRMS, but additional research is necessary to clarify their comparative effectiveness and implications for clinical practice.
