Prevalence, Severity, and Post-Transplant Mortality of Symptomatic Pleural Effusion in Adult Candidates for Liver Transplantation - Summary - MDSpire

Prevalence, Severity, and Post-Transplant Mortality of Symptomatic Pleural Effusion in Adult Candidates for Liver Transplantation

  • By

  • Ilker Kolbas

  • Adem Tuncer

  • Emrah Sahin

  • Abuzer Dirican

  • December 27, 2025

  • 0 min

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Objective:

To determine the prevalence of symptomatic pleural effusion among liver transplant candidates, compare demographic and disease-severity characteristics, and examine the association of pre-transplant pleural effusion with post-transplant mortality (30-day, 90-day, and overall).

Approach:
    Key Findings:
    • 12.8% of liver transplant candidates had symptomatic pleural effusion, with statistical significance.
    • Patients with pleural effusion exhibited higher MELD and Child-Pugh scores.
    • Pre-transplant pleural effusion was associated with increased short-term mortality post-transplant.
    Interpretation:

    Symptomatic pleural effusion in liver transplant candidates indicates more severe liver disease and correlates with worse post-transplant outcomes, highlighting the need for careful evaluation in candidate selection.

    Limitations:
    • Retrospective design may introduce selection bias.
    • Single-center study limits generalizability.
    • Potential confounding factors affecting results were not controlled.
    Conclusion:

    Symptomatic pleural effusion is prevalent among liver transplant candidates and is linked to higher mortality rates post-transplant, suggesting the need for careful consideration in candidate evaluation.

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