Universal Aspirin in High-Risk Pregnancies?
Direct dispensation at first prenatal visit delays onset, reduces rates in high-risk population without increasing hemorrhage.
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By
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Kerri Miller
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February 11, 2026
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Objective:
To evaluate the impact of universal aspirin dispensation on the rate of preeclampsia with severe features in high-risk pregnancies.
Approach:
Key Findings:
- Preeclampsia with severe features (SPE) rate decreased from 7% to 5%.
- Time to SPE diagnosis was significantly longer in the aspirin group.
- Gestational hypertension rates declined from 21% to 19%.
- Preterm delivery before 37 weeks reduced from 10% to 9%.
- Postpartum hemorrhage rates decreased from 9.5% to 8.9%.
Interpretation:
Aspirin administration in high-risk pregnancies appears to delay or prevent the onset of preeclampsia with severe features without significant harm.
Limitations:
- Observational study design limits causation inference.
- Results may not generalize to other populations with different risk profiles.
Conclusion:
Directly-dispensed aspirin in high-risk pregnancies showed promising results in reducing severe preeclampsia rates without adverse effects.
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