To identify and validate a score predicting the risk of liver-related graft discard from donors after brain death (DBD) and to assess its predictive ability for biopsy-related features and graft loss at 3 months post-transplantation, including a secondary aim to evaluate these factors.
Key Findings:
62.8% of grafts were eligible for liver transplantation, while 37.2% were discarded, highlighting the critical need for improved selection criteria.
Liver-related issues accounted for 29.8% of graft discards, with poor histology being the most common reason, underscoring the importance of histological evaluation.
The study established a new liver graft discard score with improved predictive accuracy compared to existing scores, potentially transforming graft selection.
Interpretation:
The newly developed liver graft discard score effectively predicts liver-related graft discard, which may enhance decision-making in organ allocation and increase the number of successful liver transplants.
Limitations:
Retrospective design may introduce selection bias, which could affect the generalizability of the findings.
Biopsy reviews were not centralized, potentially affecting consistency and reliability of histological assessments.
Conclusion:
The liver graft discard score is a promising tool for improving graft selection and maximizing the use of available liver organs for transplantation, potentially leading to better patient outcomes.
by Quirino Lai, Davide Ghinolfi, Alfonso W. Avolio, Tommaso M. Manzia, Gianluca Mennini, Fabio Melandro, Francesco Frongillo, Marco Pellicciaro, Zoe Larghi Laureiro, Rebecca Aglietti, Antonio Franco, Claudia Quaranta, Giuseppe Tisone, Salvatore Agnes, Massimo Rossi, Paolo de Simone
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