Construction and verification of a prediction model for sleep disorders in older patients with coronary heart disease based on machine learning algorithms - Summary - MDSpire
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Construction and verification of a prediction model for sleep disorders in older patients with coronary heart disease based on machine learning algorithms
To construct and validate a predictive model for sleep disorders in older adults with coronary heart disease (CHD) using machine learning algorithms.
Approach:
Study Design: A cross-sectional survey design was employed to collect clinical data from 338 older adult patients with CHD.
Data Collection: Participants were divided into two groups based on the presence of sleep disorders, and data were collected from questionnaires and electronic medical records.
Model Development: LASSO regression was used to screen risk factors, and Logistic regression, random forest (RF), and gradient boosting machine (GBM) models were built.
Model Evaluation: Receiver operating characteristic (ROC) and calibration curves evaluated model performance, with a temporal validation cohort of 152 older CHD patients.
Key Findings:
24.26% of patients had sleep disorders, with 58 (24.07%) in the training group.
LASSO identified five risk factors: sex, duration of CHD, chronic gastritis, anxiety, and depression.
The RF model achieved the highest AUC (0.839) and accuracy (0.766) in the training set.
In the validation set, the GBM model achieved the highest AUC (0.838) and accuracy (0.733).
The Logistic regression model demonstrated the best specificity (0.875) and F1 score (0.825).
Interpretation:
The Logistic regression, GBM, and RF models based on identified risk factors demonstrated good predictive performance for sleep disorders in older adults with CHD.
Limitations:
The study was conducted in a single hospital, which may limit generalizability.
The sample size for the validation cohort was relatively small.
Conclusion:
The study provides a scientific basis for the early identification of sleep disorder risk and targeted intervention in older patients with CHD.
In two population-based cohorts, metabolically unhealthy status generally showed higher dementia risk estimates, while metabolically healthy obesity was not associated with increased risk in primary analyses.