Artificially Sweetened and Sugar-Sweetened Beverage Intake and Risk of Liver Cancer - Summary - MDSpire

Artificially Sweetened and Sugar-Sweetened Beverage Intake and Risk of Liver Cancer

  • By

  • Cody Z. Watling

  • Longgang Zhao

  • Xinyuan Zhang

  • Emily Deubler

  • Amparo G. Gonzalez-Feliciano

  • Barry I. Graubard

  • Jessica L. Petrick

  • Aika Wojt

  • Gisela Butera

  • Jonathan N. Hofmann

  • Laura E. Beane Freeman

  • Martha J. Shrubsole

  • Wei Zheng

  • Staci L. Sudenga

  • Eva Schernhammer

  • A. Heather Eliassen

  • Lorelei A. Mucci

  • Howard D. Sesso

  • Rashmi Sinha

  • Erikka Loftfield

  • Caroline Y. Um

  • Marjorie L. McCullough

  • Mazda Jenab

  • Xuehong Zhang

  • Katherine A. McGlynn

  • June 10, 2026

  • 0 min

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Objective:

To investigate associations between intake of artificial sweetened beverages (ASB) and sugar-sweetened beverages (SSB) and the risk of total liver cancer, including hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma (ICC).

Approach:
    Key Findings:
    • IARC classified aspartame as a group 2B carcinogen based on limited evidence linking ASB to HCC, with some studies showing positive associations and others showing no significant link.
    Interpretation:

    The evidence regarding the association of ASB and SSB with liver cancer risk is not entirely consistent, highlighting the need for more comprehensive studies exploring these relationships.

    Limitations:
    • Few studies have explored associations with liver cancer subtypes other than HCC.
    • Estimates of risk associated with ASB and SSB intake vary between studies.
    • Potential biases may arise from self-reported data collection methods.
    Conclusion:

    Further research is needed to clarify the associations between artificial and sugar-sweetened beverage consumption and liver cancer risk.

Original Source(s)

Artificially Sweetened and Sugar-Sweetened Beverage Intake and Risk of Liver Cancer

  • by Cody Z. Watling, Longgang Zhao, Xinyuan Zhang, Emily Deubler, Amparo G. Gonzalez-Feliciano, Barry I. Graubard, Jessica L. Petrick, Aika Wojt, Gisela Butera, Jonathan N. Hofmann, Laura E. Beane Freeman, Martha J. Shrubsole, Wei Zheng, Staci L. Sudenga, Eva Schernhammer, A. Heather Eliassen, Lorelei A. Mucci, Howard D. Sesso, Rashmi Sinha, Erikka Loftfield, Caroline Y. Um, Marjorie L. McCullough, Mazda Jenab, Xuehong Zhang, Katherine A. McGlynn

  • June 10, 2026

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