Desflurane combined with ciprofol or esketamine improves postoperative symptoms without compromising early neurocognitive recovery after intracranial aneurysm endovascular coiling - Summary - MDSpire
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Desflurane combined with ciprofol or esketamine improves postoperative symptoms without compromising early neurocognitive recovery after intracranial aneurysm endovascular coiling
To compare the effects of three anesthetic regimens on early postoperative neurocognitive recovery and perioperative adverse events in patients undergoing endovascular coiling for intracranial aneurysms.
Key Findings:
MoCA scores improved significantly over time across all groups with no significant differences in recovery trajectories.
PONV incidence was significantly lower in the DC group (10.3%) compared to DE (17.9%) and DS (44.9%).
The DC group had the lowest incidence of dizziness (8.8%) and metoclopramide requirement.
Postoperative pain scores were significantly lower in the DE group compared to the DC group.
Interpretation:
Desflurane-based anesthesia supplemented with ciprofol or esketamine does not compromise early neurocognitive recovery.
Limitations:
The study was limited to a specific patient population undergoing endovascular coiling for aSAH.
Exclusion criteria may limit generalizability to broader populations.
Conclusion:
Desflurane plus ciprofol effectively reduces PONV and dizziness, while desflurane plus esketamine provides superior analgesia.
