Ancestry informative genetic variants associated with tobacco metabolic and detoxification capacity measured by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL) among smokers - Summary - MDSpire

Ancestry informative genetic variants associated with tobacco metabolic and detoxification capacity measured by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL) among smokers

  • By

  • Oladimeji Lanade

  • Zhongxuan He

  • Yan Zhou

  • Elizabeth Blackman

  • Denise Gibbs

  • Sharon Harrison

  • Karthik Devarajan

  • Mark Andrake

  • Roland L. Dunbrack

  • Gerald Nkogbu

  • Aditi Wagh

  • Michael Slifker

  • Cherie Erkmen

  • Freda Patterson

  • Aditi Satti

  • Heather-Dawn Lawson-Myers

  • Robin Roberts

  • Don Mitchell

  • Jeffery C. Liu

  • Joel Erblich

  • Camille Ragin

  • July 14, 2026

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Objective:

To examine the association of genetic ancestry and ancestry-informative variants in tobacco metabolism pathway genes with measures of NNAL metabolism in smokers.

Approach:
  • Study Population: The study involved 274 smokers from the Cancer Prevention Project of Philadelphia (CAP3), including individuals from the US and the Caribbean, who provided biological specimens for genetic and biochemical analyses.
  • Questionnaire Data: Participants completed a culturally tailored questionnaire designed for Black populations, adapted from the 2011 Behavioral Risk Factor Surveillance System.
Key Findings:
  • Tobacco use is a significant cause of cancer mortality, accounting for 26% of total cancer deaths globally in 2019.
  • Differences in lung cancer incidence and mortality rates exist between non-Hispanic Black and White males in the US.
  • Genetic polymorphisms in tobacco metabolism enzymes may contribute to variations in susceptibility to tobacco carcinogenesis.
Interpretation:

The study aims to examine the association of genetic ancestry and ancestry-informative variants in tobacco metabolism pathway genes with measures of NNAL metabolism in smokers.

Limitations:
  • The study is limited to smokers and may not generalize to non-smokers.
  • The sample size may restrict the ability to detect subtle genetic associations.
Conclusion:

The research seeks to clarify the relationship between genetic ancestry and tobacco metabolism.

Original Source(s)

Ancestry informative genetic variants associated with tobacco metabolic and detoxification capacity measured by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL) among smokers

  • by Oladimeji Lanade, Zhongxuan He, Yan Zhou, Elizabeth Blackman, Denise Gibbs, Sharon Harrison, Karthik Devarajan, Mark Andrake, Roland L. Dunbrack, Gerald Nkogbu, Aditi Wagh, Michael Slifker, Cherie Erkmen, Freda Patterson, Aditi Satti, Heather-Dawn Lawson-Myers, Robin Roberts, Don Mitchell, Jeffery C. Liu, Joel Erblich, Camille Ragin

  • July 14, 2026

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