Gut microbiota-dependent mechanisms and efficacy of natural polysaccharides in multitarget antidepressant therapy: a systematic review - Summary - MDSpire
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Gut microbiota-dependent mechanisms and efficacy of natural polysaccharides in multitarget antidepressant therapy: a systematic review
To summarize preclinical evidence on the antidepressant efficacy of natural polysaccharides and explore mechanisms involving the microbiota-gut-brain axis.
Approach:
Literature Search: A comprehensive search was performed in PubMed, Web of Science, and Embase for studies up to October 4, 2023, following PRISMA guidelines.
Study Inclusion: Twenty preclinical studies were included based on specific criteria related to in vivo animal experiments.
Key Findings:
Polysaccharide treatment improved depression-like behaviors and normalized neurotransmitter levels.
Treatment reduced inflammation and oxidative stress.
Changes in intestinal barrier function, gut microbiota composition, and short-chain fatty acid metabolism were observed.
High risk of bias and substantial heterogeneity were noted across studies.
Interpretation:
Natural polysaccharides exhibit potential antidepressant effects in preclinical models, but evidence remains preliminary.
Limitations:
Substantial heterogeneity in study designs and outcomes.
High risk of bias in included studies.
Conclusion:
Well-designed translational and clinical studies are needed to advance findings on the antidepressant effects of natural polysaccharides.
