Objective:

To investigate the molecular and histological responses to radiofrequency microneedling (RFMN) and assess the effects of post-treatment care with a dexpanthenol-containing ointment.

Approach:

Key Findings:

• RFMN treatment induced dermal coagulation zones that were resolved with dexpanthenol ointment.
• Transcriptomic profiling revealed an early pro-inflammatory response with upregulated chemokines and cytokines 48 hours post-treatment.
• Dexpanthenol ointment application led to increased expression of cytokines and markers of epidermal regeneration at 120 hours.

Interpretation:

The study elucidates the molecular mechanisms of RFMN and highlights the beneficial role of dexpanthenol in enhancing healing and modulating inflammation.

Limitations:

• The study was conducted in vitro, which may not fully replicate in vivo responses.
• The long-term effects of RFMN and post-treatment care were not assessed.

Conclusion:

The findings support the optimization of clinical protocols for RFMN, indicating that dexpanthenol can enhance skin rejuvenation outcomes.

Attribution Notice

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