Markers of axonal injury in blood and tissue triggered by acute and chronic demyelination - Summary - MDSpire

Markers of axonal injury in blood and tissue triggered by acute and chronic demyelination

  • By

  • Ahmed Abdelhak

  • Christian Cordano

  • Greg J Duncan

  • Katie Emberley

  • Sonia Nocera

  • Wendy Xin

  • Kirtana Ananth

  • Nour Jabassini

  • Kiarra Ning

  • Henriette Reinsberg

  • Frederike Cosima Oertel

  • Alexandra Beaudry-Richard

  • Jens Kuhle

  • Axel Petzold

  • Praveen J Patel

  • Ana P Ribeiro Reis

  • Paul J Foster

  • UKBB Eye and Vision Consortium

  • Trent Watkins

  • Jonah R Chan

  • Ben Emery

  • Ari J Green

  • April 25, 2025

  • 0 min

Share

Objective:

To assess the association between demyelination and axonal pathology through neurofilament light chain (NfL) measurements in blood and tissue, highlighting its potential as a biomarker for monitoring disease progression.

Key Findings:
  • High NfL levels correlate with peak demyelination in EAE models, suggesting a potential target for therapeutic intervention.
  • NfL levels decrease following effective remyelination, indicating recovery and potential reversibility of neuroaxonal damage.
  • NfL is associated with myelin breakdown proteins in multiple sclerosis patients, reinforcing its role as a biomarker for disease activity.
Interpretation:

NfL measurements provide a reliable biomarker for monitoring neuroaxonal injury and demyelination in both animal models and human subjects, with implications for treatment monitoring.

Limitations:
  • The study primarily focuses on specific animal models and may not fully represent human pathology, potentially limiting the generalizability of findings.
  • Longitudinal studies in diverse populations are needed for broader applicability, particularly in varying stages of demyelinating diseases.
Conclusion:

NfL serves as a promising biomarker for tracking neuroaxonal damage and recovery in demyelinating diseases, offering insights into potential therapeutic strategies and improving patient management.

Original Source(s)

Markers of axonal injury in blood and tissue triggered by acute and chronic demyelination

  • by Ahmed Abdelhak, Christian Cordano, Greg J Duncan, Katie Emberley, Sonia Nocera, Wendy Xin, Kirtana Ananth, Nour Jabassini, Kiarra Ning, Henriette Reinsberg, Frederike Cosima Oertel, Alexandra Beaudry-Richard, Jens Kuhle, Axel Petzold, Praveen J Patel, Ana P Ribeiro Reis, Paul J Foster, UKBB Eye and Vision Consortium, Trent Watkins, Jonah R Chan, Ben Emery, Ari J Green

  • April 25, 2025

Related Content

Listening to MS: AI-assisted speech analysis for diagnosis and fatigue prediction (COMMITMENT)

A Pilot, Single-Arm Feasibility Study of a Multidimensional Behavioural Intervention for Cognitive Fatigability in Multiple Sclerosis: Mental Energy Boost Program

Digging deeper into NINJ1: its multifaceted role in central nervous system diseases