Sjögren Disease—B Cells at the Brink: From Autoimmunity to Lymphomagenesis and the Rise of Novel B Cell–Targeted Therapies - Summary - MDSpire

Sjögren's Syndrome: The Role of B Cells in Autoimmunity, Lymphoma Development, and Emerging B Cell-Directed Treatments

  • By

  • Rachael A. Gordon

  • Sara S. McCoy

  • July 1, 2026

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Objective:

To explore the role of B cells in the pathogenesis of Sjögren's Syndrome (SjD) and the potential for endotyping to improve patient care.

Approach:
  • Case Presentation: A 39-year-old woman with a 15-year history of SjD complicated by leukocytoclastic vasculitis and inflammatory arthritis was presented, detailing her symptoms, treatment history, and laboratory findings.
Key Findings:
  • SjD presents with a wide range of symptoms affecting multiple organ systems.
  • Endotyping identifies three main subgroups of SjD: LSAHS, BALS, and HSA, each with distinct disease trajectories.
  • Lymphoma occurrence is associated with the BALS and HSA endotypes.
Interpretation:

Endotyping may enhance understanding of SjD and improve treatment strategies, although further research is needed.

Limitations:
  • The study of endotypes is still evolving and requires more longitudinal studies.
  • Current endotype classifications need prospective validation in diverse cohorts.
Conclusion:

Endotyping in SjD may lead to better patient management, but more research is necessary to validate these findings and their clinical application.

Original Source(s)

Sjögren Disease—B Cells at the Brink: From Autoimmunity to Lymphomagenesis and the Rise of Novel B Cell–Targeted Therapies

  • by Rachael A. Gordon, Sara S. McCoy

  • July 1, 2026

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